Discriminating self from non-self in nucleic acid sensing
نویسندگان
چکیده
منابع مشابه
A self-replicating peptide nucleic acid.
While the non-enzymatic ligation and template-directed synthesis of peptide nucleic acids (PNA) have been reported since 1995, a case of self-replication of PNA has not been achieved yet. Here, we present evidence for autocatalytic feedback in a template directed synthesis of a self-complementary hexa-PNA from two trimeric building blocks. The course of the reaction was monitored in the presenc...
متن کاملDesigning ordered nucleic acid self-assembly processes.
A major goal of self-assembly research is the synthesis of biomolecular structures with diverse, intricate features across multiple length scales. Designing self-assembly processes becomes more difficult as the number of species or target structure size increases. Just as the ordered assembly of a machine or device makes complex manufacturing possible, ordered (or 'algorithmic') biomolecular se...
متن کاملTowards Self-Exploring Discriminating Features
Many visual learning tasks are usually confronted by some common diiculties. One of them is the lack of supervised information, due to the fact that labeling could be tedious, expensive or even impossible. Such scenario makes it challenging to learn object concepts from images. This problem could be alleviated by taking a hybrid of labeled and unlabeled training data for learning. Since the unl...
متن کاملpatterns and variations in native and non-native interlanguage pragmatic rating: effects of rater training, intercultural proficiency, and self-assessment
although there are studies on pragmatic assessment, to date, literature has been almost silent about native and non-native english raters’ criteria for the assessment of efl learners’ pragmatic performance. focusing on this topic, this study pursued four purposes. the first one was to find criteria for rating the speech acts of apology and refusal in l2 by native and non-native english teachers...
15 صفحه اولNon-abelian self-duality from self-interaction
The non-abelian self-dual action in three dimensions is derived using the self-interaction mechanism. Self-duality in three dimensions was proposed initially by Townsend et. al. [1] as an alternative to the topologically massive theory[2]. In principle, they seem different descriptions of a locally massive spin 1 physical excitation: the self-dual theory is described by a non-gauge invariant fi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2016
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri.2016.78